The immune checkpoint adenosine 2A receptor is associated with aggressive clinical outcomes and reflects an immunosuppressive tumor microenvironment in human breast cancer

BackgroundThe crosstalk between the immune system and cancer cells has aroused considerable interest over the past decades.To escape immune surveillance cancer cells evolve various strategies orchestrating tumor microenvironment.The discovery of the inhibitory immune checkpoints was a major breakthrough due to their crucial contribution to immune e

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Reduced Numerical Approximation of Reduced Fluid-Structure Interaction Problems With Applications in Hemodynamics

This paper deals with fast simulations of the hemodynamics in large arteries by considering a reduced model of the associated fluid-structure interaction problem, which in turn allows an backplate additional reduction in terms of the numerical discretisation.The resulting method is both accurate and computationally cheap.This goal is achieved by me

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Ultrasound-guided paravertebral block for pyloromyotomy in 3 neonates with congenital hypertrophic pyloric stenosis

BACKGROUND AND OBJECTIVES: Hypertrophic pyloric stenosis is a relatively common affection of gastrointestinal tract in childhood that results in symptoms, such as projectile vomiting and metabolic disorders that imply a high risk of aspiration during anesthetic induction.In this way, the carrying out of a technique with general anesthesia and intra

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